0000005089 00000 n
nQt}MA0alSx k&^>0|>_',G! Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. Hydroquinone occurs as fine, white needles. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. 109. Then take the water and put the measurement into the microwave until boiled. Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. Hydroquinone is considered to be readily biodegrable and photodegradable. Remove contact lenses, if present and easy to do. Reddit and its partners use cookies and similar technologies to provide you with a better experience. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. :hS-g"s2Sj Ij=x'V]gPV8tt~qkAVXi|u}5;#.pl-/4JFQ.EP3&F.qa2hI{N qBmG(z#n [GN.}aazN(~8kux9#tnYwIHFuxW v9UNj&ffNW_\\Tc""8=_"7wC>svwQy\^4gF H][QzmlOI(B@ U4[Xb0,|m0*D"/#$\u(QI)RYg\;8 Yjh There are various other uses associated with its reducing power. The protective system can be an entrapment system, a single or multi-laminar system, such as by formation of vesicle, such as a liposome, or by utilizing wax, paraffin, silicone, polyethylene or any material or system which protects the retinoid from oxidation. This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. 0000003430 00000 n
HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. The aquatic toxicity of hydroquinone to fresh water fish, Daphnia, and algae was between 0.050- . Then add it to the ingredients. Compositions according to this invention may include additives or components to enhance the skin penetration of its ingredients. Have an order or account question? endstream
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Re: How to dissolve Hydroquinone to make 4 oz. Fill out the form below, and we will send you the document as soon as we can! This is a preview of subscription content, access via your institution. The Density of hydroquinone is . isosorbide, Ascorbic acid, i.e. 49, 313321 (2015). 29(3): 283-330, 1999. It is moderately soluble in water and highly soluble in alcohol. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. V)gB0iW8#8w8_QQj@&A)/g>'K t;\
$FZUn(4T%)0C&Zi8bxEB;PAom?W= Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. If youre making your lotion. For more information, please see our https://doi.org/10.1007/s10765-020-02750-4. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. Get medical attention. 4]DYR@'c Hydroquinone can lose a hydrogen cation from both hydroxyl groups to form a diphenolate ion. COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. Res. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. Natural antioxidants could replace hydroquinone derivatives used in industry. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. International Journal of Thermophysics 0000053439 00000 n
4. The method of item 1 07 wherein the hydroquinone is present in about 4%. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. Canon A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5.
Classical photo shops . By acting as a free radical scavenger, hydroquinone serves to prolong the shelflife of light-sensitive resins such as preceramic polymers.[18]. Hydroquinone is 1,4-benzenediol. A2, Designated state(s): [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Read our Privacy Notice. J. Pharm. HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| 115, 22772285 (2014), Article Sodium metabisulfite has the added advantage that it does not discolor by oxidation. Have an order or account question, find answers in our Online Support articles. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. If breathing is difficult, give oxygen. protecting the retinoids in a protective system; mixing the hydroquinone, and the protected retinoids; and. You can expect to hear back from a ChemPoint product specialist within 1 business hour. 0000000731 00000 n
Hydroquinone undergoes oxidation under mild conditions to give benzoquinone, process which is reversible. Hydroquinone is sold by chemical suppliers. Hydroquinone compositions are effective but have some undesirable side effects. Additionally, the hydroquinone compositions frequently discolor over time and turn from a whitish color to a brown or even black. 0000002198 00000 n
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Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. PubMedGoogle Scholar. Some documentation and label information may refer to the legacy brand. Eastman Hydroquinone, USP, meets or exceeds the requirements of the United States Pharmacopoeia and is produced under conditions of current good manufacturing practices (cGMP). The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Cationic salts of acidic ascorbyl esters, including inorganic salts, preferably magnesium ascorbyl phosphate, and amino acyl derivatives, preferably aminopropyl ascorbyl phosphate, are preferred in this invention. It can also be found on eBay and Amazon. 0000008435 00000 n
The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. Van Haelst, P. Heesen, F. Van Der Wielen, H. Govers, Chemosphere 29, 16511660 (1994), Article uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. Hydroquinone, like phenols are very weak acids and can be deprotonated. Add the hydroquinone to the water. If you have any specific questions, please include them in the comments section. Calorim. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. Consistent with a condensation reaction, water was determined to be the primary byproduct. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Chem. The experimental solubilities were correlated using two regression equations. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. Your document download will begin shortly. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. The obtained results show that the . This page was last modified on 19 June 2019, at 20:05. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. 2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9 An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. Data 53, 12781282 (2008), A. application/pdf Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles.
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