In a registry-based study, PR-like eruption was observed in only 12% of patients (14). Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. This site needs JavaScript to work properly. If you have pityriasis rosea, the rash with go away without treatment. eCollection 2022. Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Microorganisms. Pityriasis rosea: Signs and symptoms - American Academy of Dermatology Theyre both papulosquoamous (pap-you-lo-skway-miss) disorders, which is a term used to characterize skin disorders according to the presence of raised, discolored, scaly patches of skin. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. (2020) 33:e13878. Vaccinations have been identified to rarely cause several cutaneous reactions. Dermatol Ther. eCollection 2022. The .gov means its official. doi: 10.1111/jdv.17342. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. It is usually seen in children, adolescents, and young adults. National Library of Medicine and transmitted securely. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. (2021) 35:e4913. Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Em Rata Just Debuted a Chic Italian Bob With Baby Bangs. While unusual, one patient developed pityriasis rosea once a year for five years in a row. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Numerous scattered erythematous, Pityriasis rosea. Coronavirus: Five skin conditions linked to COVID-19 after - 9News eCollection 2022 Jul. Sprinkle bath water with an oatmeal-based bath product (Aveeno). Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. . Got an extremely itchy rash that came seemingly out of nowhere? Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. Get useful, helpful and relevant health + wellness information. Hum Vaccin Immunother. HHS Vulnerability Disclosure, Help Unable to load your collection due to an error, Unable to load your delegates due to an error. All rights reserved. PMC Pityriasis rosea Gibert type rash in an asymptomatic patient that tested positive for COVID-19. We present two cases of COVID-19 vaccine-induced pityriasis rosea. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. J Med Virol. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. (2016) 55:e33843. Develop a large patch on your skin. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A Pityriasis rosea after mRNA COVID-19 vaccination - PubMed Pityriasis Lichenoides. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Disclaimer. (2021) 60:11501. 1. | Pityriasis Rosea, COVID-19 and . ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. FOIA Pityriasis rosea is a common condition that causes discolored patches on your skin. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. (No.) (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). and transmitted securely. Federal government websites often end in .gov or .mil. At home, she underwent systemic treatment with antihistamines and topical medication with dermatocorticosteroids. Epub 2020 Jun 29. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The exanthem was self-limited in both patients over a period of a month. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. I tell my patient to use a gentle non-soap cleanser." Int J Infect Dis. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Would you like email updates of new search results? This site needs JavaScript to work properly. COVID-19 Skin Manifestation Heterogeneity - MedicineNet (Within two days, and still no.) Pityriasis Rosea. What started as a single, quarter-inch raised welt on my left rib cage eventually morphed into two, then four. National Library of Medicine To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. doi: 10.1111/jdv.17342. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). COVID-19; Vaccination; pityriasis rosea. We present two cases of COVID-19 vaccine-induced pityriasis rosea. Parakeratosis with minimal acanthosis, MeSH Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Lasers Med Sci. A virus may cause pityriasis rosea, but experts aren't sure. We evaluated the clinical and pathologic spectrum of mucocutaneous reactions following COVID-19 vaccines, observed consecutively within three large tertiary Centers of the Metropolitan City of Milan . Careers. Policy. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. sharing sensitive information, make sure youre on a federal Epub 2021 Jul 21. -, Drago F, Ciccarese G, Rebora A, Parodi A. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. doi: 10.1111/jdv.17342, 5. If you need help purchasing a product directly from Allure, go to our FAQ. Physicians should be aware that pityriasis rosea is a rare side-effect of COVID-19 vaccination.Pityriasis rosea is self-limiting and no medical treatment is usually required. Int J Dermatol. Of the reported cases, 96.7% were secondary to the Pfizer vaccine, with only 1 reported . Would you like email updates of new search results? Some treatments can alleviate related symptoms, including itching. Moreover, COVID-19 may solely induce human herpesvirus reactivation through the immunomodulatory ability of SARS-CoV-2 to reactivate latent viruses (8, 9). Lawley LP, McCall CO, Lawley TJ. 2021;35(9):e546e548. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). Epub 2022 Oct 17. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. One week before the rash, respiratory tract infection symptomatology was observed by the patient. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days. We do not endorse non-Cleveland Clinic products or services. However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. Drago F, Ciccarese G, Javor S, et al. Learning points: Why not? Some patients may have a cold before the rash. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Zendaya Shows Off Her Short Sunshine Curls. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Bethesda, MD 20894, Web Policies 2022 by the American Academy of Dermatology, Inc. According to King, an in-person skin exam is usually enough to make an accurate diagnosis, though a biopsy or blood work may be necessary for some. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Disclaimer. 6 Called a "herald patch,". Rare Heterogeneous Adverse Events Associated with mRNA-Based COVID-19 Vaccines: A Systematic Review. eCollection 2022. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Hardin J. Pityriasis Rosea. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. Table 1. The https:// ensures that you are connecting to the They indicate that eight types of rash could be signs of Covid-19, including red toes and fingers, chest eczema and pityriasis rosea (scroll down for the full list). "It looks very different.". 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders. Figure 3. Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. An official website of the United States government. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. doi: 10.1111/dth.13650, 7. Pityriasis rosea: Diagnosis and treatment - American Academy of Dermatology and transmitted securely. Factors affecting the severity of central centrifugal cicatricial alopecia. PMC Your California Privacy Rights. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. doi: 10.1111/dth.15040, 3. J Am Acad Dermatol. Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. -, Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. J Formos Med Assoc. While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. A variant called inverse pityriasis rosea can affect the skin on your neck, face, armpits (axillae) and groin, though it isnt common. 2021;184(6):11941195. If you have pityriasis rosea, it can generally be well-managed without any treatment. But some patients also are developing delayed skin reactions on. Med. J Eur Acad Dermatol Venereol. Apply a moisturizer, calamine lotion or a nonprescription . JAAD Case Rep. (2018) 4:8001. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. See your skin clear. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Shingles was another fear, as I had chicken pox when I was four, but we ruled that out too: "Shingles is a nerve-mediated process; it tends to be very painful, not so itchy," Lam says. 2022 Aug;35(8):e15601. Disclaimer. Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. -, Mahajan K, Relhan V, Relhan AK, et al. 2021;185(2):e34. The .gov means its official. 2020 Jul;33(4):e13730. Could covid-19 infection cause pityriasis rosea why? Your healthcare provider can typically diagnose pityriasis rosea after a physical exam. J Am Acad Dermatol. The clinical and pathologic spectrum of mucocutaneous reactions Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Would you like email updates of new search results? Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. Clinical findings of pityriasis rosealike eruption in the patients. (2020) 83:e5760. 2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. Accessibility Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. Dermoscopy showed dotted and linear vessels forming a network on a yellowish background, with some whitish peripheral scales (Figure 3A). Pityriasis rosea doesnt usually affect people over the age of 60. Clipboard, Search History, and several other advanced features are temporarily unavailable. Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. (2021) p. e15040. She diagnosed it as pityriasis rosea, a benign but frustratingly itchy rash that in her words just happens sometimes. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature JAAD Int. Bookshelf Some people who have had cosmetic fillers used to remove . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. Europe PMC is an archive of life sciences journal literature. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Pityriasis Rosea According to the Mayo Clinic, pityriasis rosea is a rash that usually begins as a large circular or oval spot on your chest, abdomen, or back. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Pityriasis rosea-like eruption revealing COVID-19. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2021 Aug;35(8):e491-e493. The site is secure. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Keywords: Pityriasis rosea-like eruptions following vaccination with BNT162b2 Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. Br J Dermatol 2020; 183: 431442. official website and that any information you provide is encrypted The mechanisms behind these COVID-19-related symptoms remain unclear. Epub 2021 Aug 7. The .gov means its official. doi: 10.1111/dth.13730. Under the treatment that was initiated a partial remission of the lesions after 7 days was observed. Medicines (Basel). COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.1111/bjd.20143. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. 2021 Nov 2;17(11):4097-4098. doi: 10.1080/21645515.2021.1963173. 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. Pityriasis rosea as a cutaneous manifestation of COVID19 infection Federal government websites often end in .gov or .mil. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. This reaction is self-limited and resolves in an average of 5.6 weeks. However, several adverse effects of COVID-19 vaccination have been identified. Unauthorized use of these marks is strictly prohibited. 2022 Oct 4;15:2117-2127. doi: 10.2147/CCID.S371630. 2021 Sep 7;8:752443. doi: 10.3389/fmed.2021.752443. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. Pityriasis lichenoides is a clonal T-cell disorder that may develop in response to foreign antigens (eg, infections or drugs) and may be associated with cutaneous T-cell lymphoma. This Month in JAAD International: August 2022: Cutaneous reactions to COVID-19 messenger RNA booster dose vaccination. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epub 2020 Jun 5. Epub 2021 May 10. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. Please enable it to take advantage of the complete set of features! Front. I figured a very determined mosquito had snuck into my room and attacked me through my tank top. "Any type of stress on the body can sometimes [cause them, and] any vaccine, not just the COVID one.". Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection J Eur Acad Dermatol Venereol. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases.