Because the test is invasive, many people prefer to try to control the symptoms by dietary methods. Cheese contains lower amounts of lactose than milk and is often tolerated, depending on the amount ingested. As excessive amounts of undigested sugars enter the colon, fluid is drawn in to normalise the increased osmotic pressure. These enzymes are localized in the brush border membrane of the small intestinal epithelial cells. (See J Am Diet Assoc. First, chew foods containing starch for a long period of time. If the babys lactose intolerance is secondary, as a result of a gastrointestinal tract infection or other transient condition, most specialists advise continuing breastfeeding and as the diarrhoea will gradually diminish as the underlying inflammation disappears. The advantage of this test is that it can directly measure the activity of all the disaccharidases with the exception of trehalase. After reviewing his biopsies, current lab work, what he has had responded to in the past and his symptoms his doctors are now thinking that what he has going on is due to inflammation. If you know your disaccharidase assay results, the finding may be used as an initial indication of starch-digestion capacity, based on your level of maltase-glucoamylase activity. It is an autosomal recessive disorder. ), (Genetic test of C/T(-13910) polymorphism can be used as a first stage screening test for adult-type, Close more info about Disaccharidase Deficiencies, OVERVIEW: What every practitioner needs to know. 0000051450 00000 n High-throughput tissue homogenization method and tissue-based Anyone have any experience with any of this? After doing bit of research, heres what I found: Disaccharidases are enzymes that break down complex sugars (like lactose) into simple sugars (like glucose) so that the intestine can absorb the nutrients. Genetic testing for the primary (adult-type) lactase deficiency is available in some commercial laboratories. Duodecim. IMPORTANT SAFETY INFORMATION FOR SUCRAID(SACROSIDASE) ORAL SOLUTION. Dietary restriction is usually adequate treatment. Algorithm for the diagnosis of the most frequent disaccharidase deficiency: lactose malabsorption. Please confirm that you are a health care professional. The presence of abdominal pain or diarrhea during the test is supportive evidence for a positive test. This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. But it appears not to be the same for diagnosing lactase deficiency. A single-nucleotide polymorphism (SNP) -13910 T/C upstream of the coding gene has been found to be involved in the regulation of enzyme activity. Rats were assigned to zinc deficient (ZD), control (C) or pair-fed (PF ) groups and fed for 40 d a zinc deficient (1 mg/kg) diet (ZD rats) or a similar diet supplemented with 50 mg Zn/kg (C and PF rats). 2009;125(7):766-770. Maltose tolerance is determined by consuming starch in the form of white grains and flours white bread, white rice etc. The carbohydrate content of the normal western diet is about 60% starch, 30% sucrose, and 10% lactose, and each of those is digested differently.1, Lactose is the sugar in milk. J Pediatr Gastroenterol Nutr. 26 Disaccharidase Deficiency ideas in 2022 | low fodmap diet, low fodmap recipes, fodmap recipes Disaccharidase Deficiency 26 Pins 30w L Collection by Elizabeth Herndon Similar ideas popular now Fodmap Diet Diet Low Fodmap Food List Low Fodmap Recipes Dinner Fodmap Diet Plan Ibs Fodmap Low Fodmap Foods Low Gluten Foods Healthy Fodmap Recipes Clinitest tablets give a positive reaction with glucose, galactose, fructose, maltose, and lactose (reducing sugars). The sucrase-isomaltase gene is located on chromosome 3 at locus 3q25-26. Diagnosis read more ). The reduced hydrolysis of these double sugars results in an osmotic effect in the proximal small intestine that leads to increased fluid, sugar, and other nutrient load to the terminal ileum and colon where bacterial fermentation produces gases (H2, CH4, CO2) and short chain fatty acids. 0000009875 00000 n 1987;22:24-28. You can also enjoy a variety of vegetables such as asparagus, salad greens, eggplant, peppers and onions. 0000010898 00000 n Disaccharidase deficiency J Am Diet Assoc. This involves challenge with foods containing the suspect disaccharide and monitoring for the recurrence of abdominal symptoms. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. They tried some antispasm medication that did nothing. Lactose intolerance is quite different from milk allergy, in which a persons immune system reacts to the protein in milk. This doctor had us taper more quickly off of the predinsone because she reviewed the Eosinophilic levels and they were actually normal. 0000045274 00000 n Usually the intestinal cells are producing a limited amount of enzyme, so that small doses of disaccharides in foods can be processed. Structural and functional damage to the intestine and the potential beneficial effects of dexamethasone (Dex) and thyroxine (T4) were examined in zinc-deficient rats. This time he had 11 ulcers- 9 in his colon and 2 in his stomach, also they saw patches of inflammation. The enzyme that breaks down sucrose, sucrose alpha-glucosidase, or sucrase, splits sucrose into the two monosaccharides or single sugars: glucose and fructose. They did a pill cam, which showed nothing. Malabsorption of disaccharides is not life-threatening, but you may experience episodes of watery diarrhea and abdominal discomfort when you eat foods containing disaccharides 3. As long as the amount consumed remains within an individuals limits, they should remain symptom free. 1972 Jun;60(6):478-82. 0000044025 00000 n The Licensed Content is the property of and copyrighted by DSM. A low fecal pH is characteristic of diarrhea caused by carbohydrate malabsorption. Almost all those with CSID have decreased sucrase activity, even if such sucrase activity is not entirely absent. Consequently, maldigested disaccharides lead to symptoms in a cyclical pattern:4 The initial diarrhoea caused by fermentation in the colon leads to speeding up of intestinal transit of food. Milk allergy is rare in adults and also may cause vomiting and symptoms of esophageal reflux, which are not manifestations of carbohydrate intolerance. Disaccharide deficiency (usually of lactase) can be acquired or, rarely, congenital. 1. *Artichokes, asparagus, broccoli, brussels sprouts, cabbage, and cauliflower can cause gastrointestinal gas in all individuals, not just individuals with CSID. In general, most individuals with CSID can eat plain sources of protein, including beef, pork, lamb, fish, turkey, chicken, and eggs. The amount of supplement that may be required will depend on individual tolerances to the disaccharide-containing food; some people will be able to tolerate a small amount of the food and so any deficiencies will be minimal. All rights reserved. There are multiple other conditions and diseases leading to similar symptoms. All Rights Reserved. What should happen is that complex carbohydrates (polysaccharides and oligosaccharides) are broken down by enzymes in the digestive tract into disaccharides. Yogurt is usually tolerated because it contains an appreciable amount of lactase produced by intrinsic Lactobacilli. Whole-wheat pasta, quinoa, lentils, brown rice, or wild rice are better options than more processed grains such as white rice. The condition is very rare, with 42 cases of CLD reported between 1966 and 1998 in Finland8. Food allergy affecting the digestive tract They usually only affect one disaccharide and are irreversible. Sucraid(sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of congenital sucrase-isomaltase deficiency (CSID). Sensitivity is 78% and specificity is > 95% (1 Diagnosis reference Carbohydrate intolerance is the inability to digest certain carbohydrates due to a lack of one or more intestinal enzymes. The starch, which is composed of long chains of glucose molecules, is gradually split into smaller and smaller chains by amylase enzymes. Journal of the American Dietetic Association Volume 48, Issue 4, April 1966, Pages 307-310 Diets in Disaccharidase Deficiency and Defective Monosaccharide Absorption Diets in Disaccharidase Deficiency and Defective Monosaccharide Absorption1 Bertil Lindquist 1 , Gunnar Meeuwisse https://doi.org/10.1016/S0002-8223 (21)20467-7 Get rights and content 1998;63:1078-1085. What causes this disease and how frequent is it? Carbohydrate malabsorption. 0000030173 00000 n Contents Front Matter Section 1 Patients and their treatment Section 2 Background to medicine Section 3 Cell biology Section 4 Immunological mechanisms Disaccharidase deficiency may be congenital or acquired (Table 1). Strong drugs and antibiotics . Carbohydrates are an important dietary component, providing about half of the calories in a typical Western diet. Primary congenital lactase deficiency is a rare disorder that manifests in early infancy. 2. 1984. pp. A sample of the homogenate is then mixed with each of the substrates: sucrose, lactose, and maltose. 6. Salivary amylase, the first enzyme in the process of starch digestion, is released in the mouth. Perman JA. This is called a primary deficiency. The human maltase-glucoamylase gene (MGAM) is located on chromosome 7 at locus 7q34. Breakfast cereals or grains that contain whole oats, barley, or bran are better options than more-processed, refined cereals. Sugars include monosaccharides (glucose, galactose, fructose) and disaccharides (lactose, sucrose, maltose). If so, which ones? ), Itan, Y., Jones, B. L., Ingram, C. J., Swallow, D. M., Thomas, M. G. A worldwide correlation of lactase persistence phenotype and genotypes. 2012; 55(2):S28-S30. Disaccharidases are enzymes that break disaccharides down into monosaccharides for digestion. Our doctor says it is most likely from an infection (bacteria or parasite probably from the zoo) or an atypical presentation of Crohns. In cases where mucosal recovery is possible following treatment of the underlying cause (e.g., celiac disease) complete symptom resolution can be anticipated and eventually it should be possible to resume ingestion of all disaccharidases. Hopefully he continues to feel better each day. vol. When introducing new food items, it is recommended that you wait at least three days before introducing an additional food item. In: Stanbury JB, Wybgaarden JB, Fredrickson DS, Goldstein JS, Brown MS eds. Carbohydrate intolerance is the inability to digest certain carbohydrates due to a lack of one or more intestinal enzymes. Over time, foods to which an affected individual was intolerant will be processed adequately and tolerated. Joneja JMV. Problems occur when the amount of disaccharide in the food exceeds the capacity of the enzymes to digest it. When the cause is removed, the cells will start to heal and gradually resume production of the enzymes. Infections in the digestive tract with parasites such as amoebae, helminths, nematodes, microorganisms such as Giardia lamblia, and viruses such as the rotavirus group Started having severe diarrhea & a lot pain for a day (5-25 times in a 12 hour period) this would happen 1 month. Disaccharide intolerance occurs when you don't produce the enzymes sucrase and isomaltase, which are essential for breaking down disaccharides 13. Some rats of the ZD group . 1. These individuals would most likely have normal levels of maltase and isomaltase (palatinase) activity. An affected adult may have watery diarrhea, bloating, excessive flatus, nausea, borborygmi, and abdominal cramps after ingesting lactose. var g = "dases?cc=MASTER"; After childhood, 80% of the adult population of the world starts to experience varying degrees of lactose intolerance. Human milk does not contain sucrose, maltose, or starch, so intolerance of other disaccharides is not a problem for the baby during breastfeeding. Typically these cases will manifest symptoms of pain or diarrhea during the test but are without a rise in breath hydrogen or methane levels. EGD and Colonoscopy that was normal, except for his disaccharidase levels being low- the GI doc we were seeing didnt really think this was a big deal. The only thing that has ever worked for my daughter is steroids- but the doctors dont think that is the answer and it is very frustrating when you see such a huge improvement (some times within hours) then as soon as they start to ween her off you see the decline then we end up full circle. The activity of the enzyme is then calculated by measuring the amount of glucose released from each substrate, since all of the disaccharides contain glucose which is released by the action of the enzyme on the disaccharide. Once he had to taper off the predisone, symptoms came back. I appreciate any information you find! The condition was first recognized in 1958. In all cases of disaccharidase deficiency, symptoms are confined to the digestive tract. He has had a couple times of blood in his stool throughout all of this. If the enzyme deficiency is a result of damage to the intestinal cells, caused by infection, food allergy, food protein enteropathy, or strong drugs, it is called a secondary deficiency and is usually temporary. 0000044436 00000 n The dietary carbohydrates of quantitative importance are the polysaccharide starch and the disaccharides sucrose and lactose. The disaccharides activity panel examines tissue samples, which have been taken as part of endoscopy, to gain quantitative values of lactase, sucrase, maltase, palatinase, and glucoamylase. Carbohydrate malabsorption occurs when the main dietary carbohydrates, sugars and starches, are not absorbed from the gastrointestinal (GI) tract. If available a nutritional consultation may be beneficial. 2002;2:2-4. https://testdirectory.questdiagnostics.com/test/test-detail/19701/dis, Do Not Sell/Share My Personal Information. The patient often recognizes early in life that dairy causes gastrointestinal problems and avoids eating dairy products. 1306-9. 1571-6. For example, it is suggested that you chew a bite of the food item 30 times before swallowing. trailer In the information you provided it does look like Flagyl is one of the medications used to treat it. There is no significant risk associated with enzyme replacement therapy. A small number of individuals do not produce hydrogen or methane and hence will give a false negative result. Thus, combining a high-fat food with a starch increases the time the foods remain in the small intestine and allow the starch to have more exposure to pancreatic amylase, isomaltase, and maltase in the small intestine. Register now at no charge to access unlimited clinical news, full-length features, case studies, conference coverage, and more. In infants, temporary secondary disaccharidase deficiency may complicate enteric infections or abdominal surgery. doi:10.1097/01.mpg.0000421405.42386.64, Quest Diagnostics. DSAC | Disaccharidase Activity Panel, Tissue. Classic disaccharidases small bowel biopsy results associated with congenital sucrase-isomaltase deficiency (CSID) are as follows: Decreased (usually absent) sucrase activity Decreased-to-normal isomaltase ( palatinase) activity Reduced maltase activity Decreased-to-normal lactase activity A deficiency of these enzymes in the duodenum (small intestine) results in a range of gastrointestinal symptoms. The NIH (National Institute of Health) has excellent information about this disorder, its various forms, treatments, clinical trials and research, and I would truly encourage you to read it, here: http://bit.ly/2hsXd0o. ease than previously thought? Congenital sucrase-isomaltase deficiency occurs in about 0.2% in North Americans of European origin and about 10% in the Eskimos of Greenland. Second, combine a high-starch food with a fatty food at the time of ingestion. Table sugar (white sugar, demarara sugar, brown sugar, icing sugart, etc.) Congenital lactase deficiency is a rare disease that is inherited in an autosomal recessive fashion. g 1) deficiencies were present.Sucrase activity correlated with maltase and palatinase levels (P = 0.001) but not with lactase levels (P = 0.101) ().The correlation of sucrase with maltase and . o [ abdominal pain pediatric ] jQuery("#quest").attr("href", f + g); The levels of salivary amylase are not affected by CSID. With disaccharidase deficiency, the easiest food to eliminated first is dairy. 0000000016 00000 n 1966 Apr;48(4):307-310. The specificity of the LTT ranges from 7796% and sensitivity from 7694%. Except in the case of a lactase deficiency, which improves dramatically when lactose is removed from the diet, it is often difficult to separate specific disaccharide intolerances from each other. These food items may be added at a later date, once appropriate sucrose and starch tolerance levels have been established through food diaries or logs. Serum glucose is measured before ingestion and 60 and 120 minutes after. This enzyme complex (sucrase-isomaltase) assists in the breakdown of a certain sugars (i.e., sucrose) and certain products of starch digestion (dextrins). Thus, the more a starchy food item is chewed, the greater the exposure the starchy food has to this necessary digestive enzyme. To view unlimited content, log in or register for free. with failure to thrive, hypercalcemia, and nephrocalcinosis. N Engl J Med. Lindquist B, Meeuwisse G. Diets in disaccharidase deficiency and defective monosaccharide absorption. For sucrose deficiency, Infants and Children =15 kg: 8500 international units (1 mL) per meal or snack; Children >15 kg and Adults: 17,000 international units (2 mL) per meal or snack. Im so glad, @fa7100. Similarly, maintenance of appropriate nutrition during and after infectious gastroenteritis has been shown to minimize prolonged mucosal damage. Gastroenterology. If you have tried dairy elimination, your next option is to remove all refined and added sugar from your diet. Congenital sucrase-isomaltase deficiency presenting These common symptoms are frequently misdiagnosed as a food allergy or intolerance. The treated food usually will be tolerated. The genetically programmed down-regulation of lactase in children. ), (The molecular difference between lactase persistence and nonpersistence is caused by the mutation at position -13910), (Intestinal glucoamylase deficiency can be the cause of chronic diarrhea. Primary and Secondary Disaccharidase Deficiency. The human lactase gene is located on chromosome 2q21-22. We are so ready for answers as this has pretty much taken over our lives. All Rights Reserved. Congenital or primary disaccharidase deficiencies require life-long management. vol. Sucraid(sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of congenital sucrase-isomaltase deficiency (CSID). deficiency of lactase, sucrase, and maltase). Alternatively, supplementation of dairy products with lactase of microbiologic origin may be suggested. Press; 2004:116-134. Bacterial fermentation of carbohydrates in the colon produces gases (hydrogen, carbon dioxide, and methane), resulting in excessive flatus, bloating and distention, and abdominal pain. 3401 Civic Center Blvd. No doctor in USA believes Crohns can be liver related disorder. 0000009914 00000 n Clinitest tablets cannot detect sucrose, lactulose, sorbitol, and mannitol as these are non-reducing sugar or sugar alcohols. Most contain negligible amounts of lactose and are tolerated by most lactose-intolerant individuals. In: Joneja JMV. Good choices of these types of dietary starch are whole grain breads or those made with stone-ground flour instead of processed and refined white breads. Summary The effect of iron deficiency anaemia, protein deficiency and worm infestation upon intestinal disaccharidase activity in the rat was assessed following the . Indication Sucraid (sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID). The diet should include salmon, baked beans, spinach, leafy vegetables, shrimp, green peas, oysters, broccoli and fresh fruits. In general, if an individual is consuming a wide range of the allowed foods and the condition is a secondary (temporary) deficiency, nutritional supplements should not be necessary. hA 04Fq\GczC. The foods that cause the problem must always be avoided. 0000010255 00000 n Nuts and nut butters can be a great source of calories for you. (Yogurt a well-tolerated source of milk for lactase-deficient persons. This enzyme is needed to hydrolyse sucrose, as well as limit dextrins from starches. Dh10:xDaF?~8vPu@gi!sp-lg f An elevation of at last 20 parts per million (ppm) for hydrogen or 10 ppm for methane above the basal level is indicative of a positive test for disaccharidase deficiency. High-fat foods slow the rate food moves through the small intestine. In the meantime I am also going to tag, @jay_baruch, @thankful, @mswanda, @judylindholm, @kaycigirl, @guener who have all discussed Crohns disease, and will hopefully have some insight for you. The most common form of disaccharidase disorder is lactase deficiency, when your small intestine doesnt produce enough of an enzyme (lactase) to digest milk sugar (lactose). Carbohydrate malabsorption is detected by testing a childs stool and finding a pH less than 5.5, which is caused by carbohydrate fermentation from malabsorption. N Engl J Med. The disadvantages are that the test is time consuming and requires a separate study for each individual sugar under consideration. A child who cannot tolerate lactose develops diarrhea after ingesting significant amounts of milk and may not gain weight. 0000009149 00000 n You can ask your doctor or the medical records department of your childs medical practice for a copy. vol. Lactose intolerance can usually be diagnosed with a careful history supported by dietary challenge. This restriction is necessary to determine your sucrose tolerance levels before introducing dietary starches. I am learning that the liver loves vegetables specially raw and once fed that it removes inflammation. Unless additional calcium is obtained from other food sources or supplements there is potential risk for decreased bone density. Some starches are digested more slowly in the small intestine and will slow gastric emptying, the rate at which food moves from the stomach into the small intestine and the rest of the digestive tract. Then he would go back to normal for the rest of the time. Connect with thousands of patients and caregivers for support, practical information, and answers. quality control materials for a clinical assay of the intestinal disaccharidases. Gradual reintroduction of disaccharides, one by one, should determine exactly which disaccharide is not tolerated. 4. Sucrase: Abnormal Range is less than 25 U* 0000013611 00000 n Thank, Now I am 72 years old. 0000020978 00000 n 0000010370 00000 n A serving size or more of each of the relevant food types (see below) should be consumed. It is absolutely amazing, he is a different kid! 53. Sucrose tolerance levels may be determined by introducing increasing amounts of sugar-containing foods slowly, combined with Sucraid (sacrosidase) Oral Solution to help limit gastrointestinal symptoms. The most common form of disaccharidase disorder is lactase deficiency, when . These make their way through the gut wall into the blood stream. *Our current doctor is addressing the low Disaccharidase levels, it was the first GI doctor that never really addressed them. Working with a registered dietitian is crucial to dietary success. Had a CT scan that showed thickening of the ileum and mesenteric adenitis. Drugs, inflammatory diseases and pathogens can cause direct damage to the enterocytes or adversely affect cell turnover in the small intestine. The parents of a child with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. Congenital (eg, rare deficiencies of lactase or sucrase-isomaltase), Acquired lactase deficiency (primary adult hypolactasia) is the most common form of carbohydrate intolerance. Your use of this website constitutes acceptance of Haymarket Medias Privacy Policy and Terms & Conditions. Primary forms of lactase deficiency (congenital lactase deficiency or primary hypolactasia) will have complete symptom resolution if therapeutic recommendations are followed. *The GI doctor doesnt think it is Crohns but is not ruling it out. 1. (Intestinal glucoamylase deficiency can be the cause of chronic diarrhea. Once sucrose tolerance levels have been established, you may begin to slowly introduce foods containing starches. Connect with thousands of patients and caregivers for support and answers. (Genetically programmed down-regulation of the lactase gene is detectable in children from the second year of life, although the onset and extent are somewhat variable. Gudmand-Hoyer E, Fenger HJ, Kern-Hansen P, Madsen PR. Diarrhea secondary to disaccharidase deficiency typically results in an increased stool osmotic gap (>125 mOsm/kg). In the long-term elimination of all dairy products can result in decreased calcium intake. It is important to determine starch tolerance by introducing starch-containing foods gradually. %%EOF The monosaccharides are then absorbed through the gut wall, into blood. There are several types of carbohydrate malabsorption, including: Our experts are available to consult with you or your physician on second opinion requests. Some can tolerate regular, non-diet sodas that are sweetened with high fructose corn syrup. Congenital deficiencies of disaccharidases and the primary lactase deficiency are due to genetic variations. Inherited (congenital) deficiency in components of transport systems needed to move the sugars from the intestine into circulation. You are encouraged to report negative side effects of prescription drugs to the FDA. hb```b``f`c` @QGL&``3KW;8$ Usually this disorder occurs in babies and children tend to outgrow it as they age. Maltose restricted: vitamin B complex. Starches are typically found in grains such as wheat, potatoes, corn, and rice. She said if it is it is an atypical presentation. Disaccharides are normally split into monosaccharides by disaccharidases (eg, lactase, maltase, isomaltase, sucrase [invertase]) located in the brush border of small-bowel enterocytes. 7. The Health Professionals Guide to Food Allergies and Intolerances by Dr Janice Joneja, published by Academy of Nutrition and Dietetics and available here on Amazon. *For now she is having him take the Flagyl for 2 weeks and then we are going to see how he responds Avoid consuming dairy foods or foods processed in an environment where they may come into contact with dairy. You need to read labels carefully because some whole grain products contain added sugars, including sucrose. Dr Crohns stated that the disease impacts the liver but he didnt conclude saying that a clean liver controls the disease. endstream endobj 1909 0 obj <>/Filter/FlateDecode/Index[105 1762]/Length 60/Size 1867/Type/XRef/W[1 1 1]>>stream They are hoping to keep him on Prednisone for a while and then taper off of it, then hopefully the Apriso is able to maintain the inflammation. The osmotic effect may be large enough to cause diarrhea, which is explosive when gas also accompanies the liquid stool. Mayo Clinic Laboratories now offers a test to evaluate patients for disaccharidase deficiency when serological testing, X-ray and ultrasound imaging, and breath testing come back negative. In addition to sugars and fibers, starch is a component of some carbohydrates. The molecular basis for primary disaccharidase deficiencies still is unclear. This results in abdominal bloating, pain, and flatulence (wind). Secondary lactase deficiency occurs in conditions that damage the small-bowel mucosa (eg, celiac disease Celiac Disease Celiac disease is an immunologically mediated disease in genetically susceptible people caused by intolerance to gluten, resulting in mucosal inflammation and villous atrophy, which causes malabsorption read more , tropical sprue Tropical Sprue Tropical sprue is a rare acquired disease, probably of infectious etiology, characterized by malabsorption and megaloblastic anemia. Continuing Medical Education (CME/CE) Courses. So the undigested lactose moves into the colon, where it provides an excellent base for microbial fermentation. Monosaccharide sugars are normally efficiently absorbed in the small intestine. Jarvela I, Enattah NS, Kokkonen J, Varilo T, Savilahti E, Peltonen L. Assignment of the However, this is a non specific finding and hence imaging studies have no role in the diagnosis of disaccharidase deficiencies. and response to an exclusion diet are the diagnostic procedures for lactase deficiency. Human milk contains 6% (weight in volume) lactose compared to 4% in cows milk. An example of this combination is a fatty cheese dip with a starchy vegetable.